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Kane And Lynch: Dead Men follows the main protaginists: Kane (Marcus Adam) and James Lynch on their forced journey to aid the mercenary group known as: The7 in order to save Kane's family.

Eventually, Kane and Lynch get betrayed by the members of The7 and retaliate in order to secure safety for Kane's daughter, Jenny. Little is known about what The7 wants, or Kane's list of what he calls "Dead Men." But one thing is for sure, they will get brutal revenge.